UFC 317 predictions, best bets, odds: Charles Oliveira, Alexandre Pantoja among top picks to consider

The biggest MMA event of the summer is here as UFC is back in Las Vegas to celebrate International Fight Week. The promotion caps off an incredible week in Sin City on Saturday night with UFC 317, which is headlined by a pair of big title fights. In the main event, former featherweight champion Ilia Topuria makes the move to lightweight, where he'll take on former champ Charles Oliveira for the vacant title. Topuria vacated his featherweight title to pursue lightweight glory and he will enter the Octagon as a considerable favorite against Oliveira. The flyweight title fight, meanwhile, features another P4P great in Alexandre Pantoja, who is looking for his fourth defense of the crown. 

The Brazilian has cleaned out the majority of the 125-pound class as he owns wins over the majority of the ranked opponents in the division. He gets a fresh face in Kai Kara-France, but the New Zealand native is just 1-2 in his last three fights. He scored a stunning knockout of Steve Erceg last time out to earn this opportunity. With two titles on the line and meaningful action across other weight classes, there is sure to be plenty of interest at sportsbooks around the country and we're here to give our picks for the best bets for each of the five UFC 317 main card fights.

After a slightly disappointing 2-3 result for our best bets for UFC 316, our 2025 record still sits respectably at 16-12. We'll look to get our roll going again on Saturday, with our only rule remaining that all bets must be at odds of -250 or better. Let's take a look at this week's picks with odds via DraftKings.